个人信息

姓名: 李远

性别: 男

职称: 研究员

职务: GCP办公室主任、重庆市老年疾病临床研究中心执行主任

联系信息

邮箱: liyuan_1985999@163.com

地址: 重庆市永川区萱花路439号

教育经历

2013.09-2016.07：重庆医科大学，临床检验诊断学博士

2007.09-2009.12: 重庆大学，生物医学工程，硕士

1990.09-1995.07: 重庆医科大学，临床医学，学士

工作经历

2010.08-2015.02，重庆医科大学附属永川医院中心实验室科研人员

2015.03-2017.12，重庆医科大学附属永川医院中心实验室助理研究员

2018.01-2022.12，重庆医科大学附属永川医院中心实验室副研究员

2023.01 至今，重庆医科大学附属永川医院中心实验室研究员

研究方向

1、基于微流控芯片的出凝血和血小板功能体外诊断新技术的开发及临床应用；2、利用微流控血管器官模型研究血小板力学生物学效应及机制； 3、中医药活性成分抗血小板药效及药理；4、药物/纳米材料/植入性生物材料的血液相互作用评价（GB/T 16886.4）。

主持项目

重庆市科卫联合医学科研项目中青年高端人才项目, 2023GDRC008，一种新型微流控血小板功能分析技术的临床转化研究  12万元，在研，主持

重庆市高等教育教学改革研究项目, 233168, TRIZ理论在提升医学生创新能力的应用模式研究, 2万元，在研，主持

国家自然科学基金青年科学基金项目，11702047 ，高仿生体外微血管模型分析糖尿病视网膜病变患者白细胞与血管内皮细胞间的粘附行为，20万元，结题，主持

重庆市博士后科研项目特别资助项目， Xm2017082，“高仿生微血管模型分析糖尿病视网膜病变患者白细胞粘附行为，5万元，结题，主持

重庆市科学技术委员会社会事业与民生保障科技创新专项（一般），cstc2017shms130009， 微流控芯片POCT凝血仪的研发和推广，20万元，结题, 主持

发表论文

1. Xuemei Gao, Tiancong Zhang, Xiaojing Huang, Xuanrong Huan, Yuan Li（通讯作者）. Evaluate the effect of the rise and fall phase of shear on platelet activation and aggregation in microfluidics. Journal of Thrombosis and Thrombolysis. 2024,3,31

2. Jiangman Tian, Qihao Zhu, Xiaojing Huang, Yuan Li（通讯作者）. A new sandwich-type electrochemiluminescence sensor based on HPSNs-NH2@Au NPs and AuPdPt NPs for determination of α(2,3)-sial-Gs. Microchimica Acta.2023, 420. Online

3. Tiancong Zhang, Ling Liu, Xiaojing Huang, Xuemei Gao, Xuanrong Huan, Cui He, Yuan Li（通讯作者）. The rapid change of shear rate gradient is beneficial to platelet activation. Platelets. 2024, 35(1): 2288679.

4. Zhanshu Liu, Xiaojing Huang, Xuemei Gao, Tiancong Zhang, Cui He, Ling Ding, Yuan Li（通讯作者）. Anti-platelet agents inhibit platelet adhesion and aggregation on glass surface under physiological flow conditions: Toward a microfluidic platelet functional assay without additional adhesion protein modification. Journal of Cardiovascular Pharmacology（J Cardiobasc PharmacolTM）,2024,83:173-182.

5. Xuemei Gao, Tiancong Zhang, Xiaojing Huang, Xuanrong Huan, Yuan Li（通讯作者）.  Evaluating the impact of transient shear stress on platelet activation, adhesion and aggregation with microfluidic chip technique. Artificial Organs. 2024,48(1): 28-36  

6. 高雪梅，张天聪, 黄小静,宦宣容, 李 远（通讯作者）. 运用微流控技术分析虫草素对剪切诱导血小板聚集和活化的抑制效果[J].中国药学杂志. 2024,59(6): 541-548

7. 三七三醇皂苷主要成分抑制剪切力诱导的血小板活化和聚集[J].陆军军医大学学报, 2023, 45(19): 2037-2044

8. Sheng, Donghai; Zhang, Lin; Shang, Hongfei ; Guo, Baoming; Yuan Li(共同通讯作者). The surface of PMP hollow fiber membrane was modified with diamond-like carbon (DLC) film to enhance the blood compatibility of artificial lung membrane. Langmuir, 2023, 39(37): 13258-13266

9. Sheng, Donghai; Zhang, Lin; Huo Jia; Baoming Guo; Xiangjun Zhang, Yuan Li(共同通讯作者). Phosphorylcholine/Heparin Composite Coatings on Artificial Lung Membrane for Enhanced Hemo-compatibility. Langmuir,2023,39,9796-9806

10. Yingshuai Liu, Xiaoling Liao; Jingjing Nie; Xiangyang Yuan; Zhao Feng; Endian Cui; Yuan Li(共同通讯作者); Yang Wu, Carbopol dispersed U@PAA with high colloidal stability as a combination nano-adjuvant boosts immune responses and protection against pseudorabies virus in mice and pigs. Acta Biomaterialia, 2023,168, 540-550  

11. Xuemei Gao, Tiancong Zhang, Xiaojing Huang, Xuanrong Huan, Cui He, Yuan Li(通讯作者). Cordycepin inhibits Pathological high shear-induced platelet aggregation, activation and phosphatidylserine exposure by regulating the phosphorylation of Akt protein.  Rev. Bras. Farmacogn. 2023, 33, 768-777

12. Tiancong Zhang, Ling Liu, Xiaojing Huang, Xuemei Gao, Dan Chen, Xuanrong Huan, Cui He, Yuan Li(通讯作者). Effect of pathological high shear exposure time on platelet activation and aggregation. Clinical Hemorheology and Microcirculation. 2023, 84:125-139

13. Xiaojing Huang, Tiancong Zhang, Xuemei Gao, Xuanrong Huan, Yuan Li(通讯作者). Novel Antiplatelet Activity of Ginsenoside Re through the Inhibiton of High Shear Stress-Induced Platelet Aggragation. Journal of Cardiovascular Pharmacology（J Cardiobasc PharmacolTM）. 2023, 82(1):40-51.

14. Tiancong Zhang, Ling Liu, Xiaojing Huang, Xuemei Gao, Dan Chen, Xuanrong Huan, Cui He, Yuan Li(通讯作者). Application of microfluidic chip technology to study the inhibitory effect of tetramethylpyrazine on platelet aggregation, activation , and phosphatidylserine exposure mediated by pathological high shear rate. Blood Coagulation & Fibrinolysis.  2023,34(1): 47-60

15. 张天聪，黄小静，高雪梅，宦宣容，何翠，李远（通讯作者）. 应用微流控方法评估抗血小板药物对剪切诱导的血小板活化和聚集的抑制作用. 医用生物力学，2023,38（5）：931-937  

16. 黄小静,张天聪,高雪梅,何翠,宦宣容, 李远（通讯作者）. 微流控芯片技术和流式细胞术检测替格瑞洛抗血小板疗效. 中国医学科学院学报,2023,45(02):257-263.

17. Ke Ning, Huihui Chai, Yanxia Cui, Shiming Wu, Feng Chen, Yuan Li(共同通讯作者)，Ping Qiu, Wei Sun, Ling Yu. Fast detection of β2 microglobulin in patient blood by a handheld centrifugal microfluidics device. Sensors and Actuators B: Chemical, 2022, 373: 132737

18. WU You, XIAO Wen-Hai, DING Ling, CHEN Dan, DENG Su-Rong, LI Yuan（通讯作者）. Performance Evaluation of a New Microfluidic Platelet Function Test Platform. 中国实验血液学杂志，2022,30（6）：1893-1901

19. 高雪梅，黄小静，张天聪，宦宣容，陈丹，何翠，李远（通讯作者）. 运用微流控技术分析替罗非班对剪切力诱导血小板聚集的抑制效果. 医用生物力学，2023, ,2023,38(3): 608-614

20. 张天聪, 陈丹, 廖娟, 邓素容, 米永华, 刘占术, 何菲, 胡煜琳, 李远（通讯作者）.生理性流动条件下血小板在玻璃表面的聚集行为研究.医用生物力学.2022,37(3): 425-432

21. 何菲, 张天聪, 陈丹, 丁玲, 邓素容, 米永华, 刘占术, 李远（通讯作者）. 显微三维成像技术分析替罗非班抑制血小板黏附聚集的量效关系.分析化学, 2022, 50(2): 244-252.

22. Cui He, Lihua Yu, Wenran Dan, Surong Deng, Haidong Ma, Beizhong Liu, Yuan Li（共同通讯作者）.Application of a Simple Microfluidic Chip Analysis Technology to Evaluate the Inhibitory Role of Protocatechuic Acid on Shear-Induced Platelet Aggregation[J]. Evid Based Complement Alternat Med., 2021, 2021:5574413.