邓春
教授
详细介绍
工作经历
工作经历
1991.07-1996.06 重庆医科大学附属儿童医院住院医师
1996.07-2002.06 重庆医科大学附属儿童医院主治医师
2002.07-2010.06 重庆医科大学附属儿童医院副主任医师/副教授
2010.07-2019.10 重庆医科大学附属儿童医院主任医师/教授
2019.10-至今 重庆医科大学附属永川医院主任医师/教授
研究方向(含承担课题)
研究方向
熟悉危重新生儿，尤其是早产儿，超早产儿的抢救和治疗，主要研究方向为超早产儿支气管肺发育不良的机制研究，先后以项目负责人获得国家自然科学基金项目2项。1991年毕业于重庆医科大学儿科系获得学士学位，同年以优异的成绩留任于重庆医科大学附属儿童医院工作，于2004年获得博士学位。2007年10月-2008年10月，在日本冈山医疗中心新生儿重症监护室作访问学者；2013年赴美国哈佛大学Beth Israel Medical Center新生儿中心进修学习。
主持项目
1. 国家自然科学基金面上项目，30770950，上皮-间质转换(EMT)与骨髓前体细胞对支气管肺发育不良成纤维细胞相对贡献评价，2008/01-2010/12，30万元，已结题，主持
2.国家自然科学基金面上项目，81270058，弹性蛋白平衡在肺泡化阻滞中的作用：支气管肺发育不良发病关键机制，2013/01-2016/12，70万元，已结题，主持
3.重庆市自然科学基金“支气管肺发育不良病人外周血纤维细胞检测及意义”(CSTC, 2009BB6072)，2009.1-2011.12，经费3万。项目主持人。
著作论文
发表论文
1.Tian B, Zhang Y, Deng C, Guo C. Efficacy of Probiotic Consortium Transplantation on Experimental Necrotizing Enterocolitis. J Surg Res. 2022，279:598-610. doi: 10.1016/j.jss.2022.05.030.
2. Mo D, Deng C, Chen B, Ding X, Deng Q, Guo H, Chen G, Ye C, Guo C. The severity of NEC is ameliorated by prostaglandin E2 through regulating intestinal microcirculation. Sci Rep. 2023 ，13(1):13395. doi: 10.1038/s41598-023-39251-x.
3.Luo Y, Mo D, Guo H, Ye C, Chen B, Zhu H, Deng C, Deng Q, Guo C, Qiu L. NF-κB inactivation attenuates the M1 macrophage polarization in experimental necrotizing enterocolitis by glutaredoxin-1 deficiency. Cell Biol Int. 2022，46(11):1886-1899. doi: 10.1002/cbin.11861.
4.Yu B, Li X, Wan Q, Han W, Deng C, Guo C. High-Mobility Group Box-1 Protein Disrupts Alveolar Elastogenesis of Hyperoxia-Injured Newborn Lungs. J Interferon Cytokine Res. 2016 ，36(3):159-68. doi: 10.1089/jir.2015.0080.
5. Zeng S, Li X, Deng C, Li L, Guo C. Evaluation of parenteral nutrition-associated liver disease in surgical infants for necrotizing enterocolitis. Medicine (Baltimore). 2020 ，99(2):e18539. doi: 10.1097/MD.0000000000018539.
6.Zhang X, Tian B, Deng Q, Cao J, Ding X, Liu Q, Zhang Y, Ye C, Deng C, Qiu L, Guo C. Nicotinamide riboside relieves the severity of experimental necrotizing enterocolitis by regulating endothelial function via eNOS deacetylation. Free Radic Biol Med. 2022 ，1;184:218-229. doi:10.1016/j.freeradbiomed.
7.Li C, Li X, Deng C, Guo C. Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia. PLoS One. 2016 ，11(6):e0157181. doi: 10.1371/journal.pone.0157181.
8.Zhang H, Chen J, Wang Y, Deng C, Li L, Guo C. Predictive factors and clinical practice profile for strictures post-necrotising enterocolitis. Medicine (Baltimore). 2017 ，96(10):e6273. doi: 10.1097/MD.0000000000006273.
9. Deng S, Zhang H, Han W, Guo C, Deng C. Transforming Growth Factor-β-Neutralizing Antibodies Improve Alveolarization in the Oxygen-Exposed Newborn Mouse Lung. J Interferon Cytokine Res. 2019 ;39(2):106-116. doi: 10.1089/jir.2018.0080.
10.Wang H, Wang Y, Deng C, Li L, Guo C. Prediction of intestinal failure from necrotizing enterocolitis following surgery: A multicenter retrospective review. Medicine (Baltimore). 2019 ;98(19):e15568. doi: 10.1097/MD.0000000000015568.
11.Han W, Li X, Zhang H, Yu B, Guo C, Deng C. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia. Int J Biochem Cell Biol. 2017 ，92:173- 182. doi: 10.1016/j.biocel.2017.08.004.
12.Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, Guo C. Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation. Cell Physiol Biochem. 2015;36(6):2198-216. doi: 10.1159/000430185.
13. Li X, Li L, Wang Y, Deng C, Guo C. Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages. Medicine (Baltimore). 2017 ，96(32):e7774. doi: 10.1097/MD.0000000000007774.
14.Xie X, Guo S, Deng C, Guo C. Postoperative outcomes based on crystalloid administration in pediatric patients with necrotizing enterocolitis undergoing laparotomy. Medicine (Baltimore). 2020 ，99(40):e21987. doi:
10.1097/MD.0000000000021987.
15.You Y, Guo C, Zhang H, Deng S, Tang J, Xu L, Deng C, Gong F. Effect of Intranasal Instillation of Lipopolysaccharide on Lung Development and Its Related Mechanism in Newborn Mice. J Interferon Cytokine Res. 2019
，39(11):684-693. doi: 10.1089/jir.2019.0006.
16. Liu Y, Qingjuan S, Gao Z, Deng C, Wang Y, Guo C. Circulating fibrocytes are involved in inflammation and leukocyte trafficking in neonates with necrotizing enterocolitis. Medicine (Baltimore). 2017 ，96(26):e7400. doi:
10.1097/MD.0000000000007400.
17.Deng C, Wang J, Zou Y, Zhao Q, Feng J, Fu Z, Guo C. Characterization of fibroblasts recruited from bone marrow-derived precursor in neonatal bronchopulmonary dysplasia mice. J Appl Physiol (1985). 2011 ，111(1):285-94. doi: 10.1152/japplphysiol.00201.2010.
18. Pu CL, Guo CB, Jin XQ, Deng C, Zhang MM, Li YC, Kang Q. Retrospective analysis of maternal and infant birth features of hepatoblastoma patients Zhong hua Gan Zang Bing Za Zhi. 2009 ，17(6):459-61.
19. Deng C, Li X, Zou Y, Wang J, Wang J, Namba F, Hiroyuki Y, Yu J, Yamauchi Y, Guo C. Risk factors and pathogen profile of ventilator-associated pneumonia in a neonatal intensive care unit in China. Pediatr Int. 2011 ，53(3):332-7. doi:10.1111/j.1442-200X.2011.03382.x.
20. Feng J, Deng C, Yu JL, Guo CB, Zhao QQ. Expression of high mobility group protein-B1 in mice with hyperoxia-induced bronchopulmonary dysplasia. Zhongguo Dang Dai Er Ke Za Zhi. 2010 ，12(3):219-23. Chinese.
21.Liu X, Li K, Zhang F, Zhang Y, Deng C, Guo C. Ablation of glutaredoxin 1 promotes pulmonary angiogenesis and alveolar formation in hyperoxia-injured lungs by modifying HIF-1α stability and inhibiting the NF-κB pathway. Biochem Biophys Res Commun. 2020 ，525(2):528-535. doi: 10.1016/j.bbrc.2020.02.129.
22. Guo CB, Wang S, Deng C, Zhang DL, Wang FL, Jin XQ. Relationship between matrix metalloproteinase 2 and lung cancer progression. Mol Diagn Ther. 2007，11(3):183-92. doi: 10.1007/BF03256240.
23. Jin X, Qiu L, Zhang D, Zhang M, Wang Z, Guo Z, Deng C, Guo C. Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs
via NF-kappaB and mitochondrial cytochrome c cascade. J Cell Mol Med. 2009 ，13(11-12):4596-607. doi: 10.1111/j.1582-4934.2008.00601.x.
24. Deng C, Guo CB, Xu YH, Deng B, Yu JL. Three mutations analysis of glucose-6-phosphate dehydrogenase deficiency in neonates in South-west China. Pediatr Int. 2007 ，49(4):463-7. doi: 10.1111/j.1442-200X.2007.02398.x.
25. Jin X, Wang Z, Qiu L, Zhang D, Guo Z, Gao Z, Deng C, Wang F, Wang S, Guo C. Potential biomarkers involving IKK/RelA signal in early stage non-small cell lung cancer. Cancer Sci. 2008 ，99(3):582-9. doi: 10.1111/j.1349-7006.2007.00713.x.
26. Han W, Guo C, Liu Q, Yu B, Liu Z, Yang J, Deng C. Aberrant elastin remodeling in the lungs of O₂-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin. Cell Tissue Res. 2015 ，359(2):589-603. doi: 10.1007/s00441-014-2035-1.
27. Gao Z, Shang Q, Liu Z, Deng C, Guo C. Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. Oncotarget. 2015 ，6(34):36338-53. doi: 10.18632/oncotarget.5537.
28. Zhang D, Jin X, Wang F, Wang S, Deng C, Gao Z, Guo C. Combined prognostic value of both RelA and IkappaB-alpha expression in human non-small cell lung cancer. Ann Surg Oncol. 2007 ，14(12):3581-92. doi: 10.1245/s10434-007-9560-z.
29. Qiu L, Deng C, Fu Z, Guo C. The role of transforming growth factors beta1 and beta3 in pre- and post-natal pulmonary surfactant development. Cell Biol Int. 2011 ，35(3):287-92. doi: 10.1042/CBI20090486.
30. Liu FJ, Deng C, Guo CB, Fu Z. Effect of hyperoxia and TGF-β1 on epithelial-mesenchymal transition of type II alveolar epithelial cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 ，28(5):474-7.
31. Deng C, Guo CB, Yu JL, Wu SX, Tan Y. Expression of Ref-1 and FAP-1 mRNA in hypoxic-ischemic injury in neonatal rat]. Zhong hua Er Ke Za Zhi. 2003 ，41(4):297-9.
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